Eine Überprüfung der Methadontabletten zur Schmerzbehandlung
Eine Überprüfung der Methadontabletten zur Schmerzbehandlung
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Because of the potential for serious adverse reactions hinein nursing infants from methadone, a decision should Beryllium made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.
The use of methadone rein patients already known to have a prolonged QT interval has not been systematically studied.
When methadone is used with certain drugs, it may not work as well to treat your condition. This is because the amount of methadone hinein your body may Beryllium decreased. Examples of these drugs include:
Geriatric – The pharmacokinetics of methadone have not been evaluated rein the geriatric Individuenbestand.
Acute Pain – Maintenance patients on a stable dose of methadone who experience physical trauma, postoperative pain or other acute pain cannot Beryllium expected to derive analgesia from their existing dose of methadone. Such patients should Beryllium administered analgesics, including opioids, in doses that would otherwise Beryllium indicated for non-methadone-treated patients with similar painful conditions.
Patients developing QT prolongation while on methadone treatment should be evaluated for the presence of modifiable risk factors, such as concomitant medications with cardiac effects, drugs which might cause electrolyte abnormalities, and drugs which might act as inhibitors of methadone metabolism. For use of methadone to treat pain, the risk of QT prolongation and development of dysrhythmias should be weighed against the benefit of adequate pain management and the availability of alternative therapies.
If you have a paralytic ileus (lack of muscle tone hinein the intestines that can cause GI obstructions), you shouldn’t take this drug.
For people with a gastrointestinal (Us-soldat) obstruction: This drug can cause constipation and increase your risk of a GI obstruction. If you have a history of GI obstructions or you currently have one, you should talk to your doctor about whether this drug is safe for you.
Methadone should Beryllium used with caution in elderly and debilitated patients; patients who are known to be sensitive to central nervous Gebilde depressants, such as those with cardiovascular, pulmonary, renal, or hepatic disease; and in patients with comorbid conditions or concomitant medications which may predispose to dysrhythmia.
The safety and effectiveness of this drug hasn’t been established in children. It shouldn’t Beryllium used rein children younger than 18 Methadontabletten 10 mg online years.
The decrease rein plasma half-life and increased clearance of methadone resulting hinein lower methadone trough levels during pregnancy can lead to withdrawal symptoms rein some pregnant patients. The dosage may need to be increased or the dosing interval decreased hinein pregnant patients receiving methadone (see PRECAUTIONS, Pregnancy, Laboratorium and Delivery, and DOSAGE AND ADMINISTRATION).
Anxiety – Since methadone as used by tolerant patients at a constant maintenance dosage does not act as a tranquilizer, patients Weltgesundheitsorganisation are maintained on this drug will react to life problems and stresses with the same symptoms of anxiety as do other individuals.
Desipramine – Blood levels of desipramine have increased with concurrent methadone administration.
Take your next dose the following day as scheduled. Don’t take extra doses. Taking more than the prescribed dose may cause you to overdose because this drug builds up rein your body over time.